Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)

被引：113

作者：

Grimm T. ^{[1
]}

Chovanová Z. ^{[2
]}

Muchová J. ^{[2
]}

Sumegová K. ^{[2
]}

Liptáková A. ^{[2
]}

Ďuračková Z. ^{[2
]}

Högger P. ^{[1
]}

机构：

[1] Institut für Pharmazie und Lebensmittelchemie, Bayerische Julius-Maximilians-Universität, Würzburg

[2] Department of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava

来源：

Journal of Inflammation | / 3卷 / 1期

关键词：

Human Monocyte; Pycnogenol; Pine Bark Extract; Counting Living Cell; Matched Plasma Sample;

D O I：

10.1186/1476-9255-3-1

中图分类号：

学科分类号：

摘要：

French maritime pine bark extract (Pycnogenol®) displays a variety of anti-inflammatory effects in vivo. Aim of this study was to determine whether human plasma after oral intake of Pycnogenol contains sufficient concentrations of active principles to inhibit key mediators of inflammation. Blood samples from seven healthy volunteers were obtained before and after five days administration of 200 mg Pycnogenol per day. Plasma samples statistically significantly inhibited matrix metalloproteinase 9 (MMP-9) release from human monocytes and NF-κB activation. Thus, we provide evidence that bioavailable active principles of Pycnogenol exert anti-inflammatory effects by inhibition of proinflammatory gene expression which is consistent with documented clinical observations. We suggest that our ex vivo method is suitable to substantiate molecular pharmacological mechanisms of complex plant extracts in a more focussed and rational way compared to in vitro studies by taking into account the processes of absorption and metabolism. © 2006Grimm et al; licensee BioMed Central Ltd.

引用

共 25 条

[1]

Rohdewald P., A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology, Int J Clin Pharmacol Ther, 40, pp. 158-168, (2002)

[2]

Maritime Pine Extract, United States Pharmacopeia Volume 28, 28, pp. 2115-2116, (2005)

[3]

Hosseini S., Pishnamazi S., Sadrzadeh S.M., Farid F., Farid R., Watson R.R., Pycnogenol((R)) in the Management of Asthma, J Med Food, 4, pp. 201-209, (2001)

[4]

Lau B.H., Riesen S.K., Truong K.P., Lau E.W., Rohdewald P., Barreta R.A., Pycnogenol as an adjunct in the management of childhood asthma, J Asthma, 41, pp. 825-832, (2004)

[5]

Farid R., Mirteizi A., Mirheidari M., Rezaieyazdi S., Mansouritorghabeh H., Zibadi S., Watson R.R., Pycnogenol® reduces clinical symptoms of knee osteoarthritis, Arthritis Care Res

[6]

Kyriazi M., Yova D., Rallis M., Lima A., Cancer chemopreventive effects of Pinus Maritima bark extract on ultraviolet radiation and ultraviolet radiation-7,12,dimethylbenz(a)anthracene induced skin carcinogenesis of hairless mice, Cancer Lett, (2005)

[7]

Sime S., Reeve V.E., Protection from inflammation, immunosuppression and carcinogenesis induced by UV radiation in mice by topical Pycnogenol, Photochem Photobiol, 79, pp. 193-198, (2004)

[8]

Packer L., Rimbach G., Virgili F., Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol, Free Radic Biol Med, 27, pp. 704-724, (1999)

[9]

Rohdewald P.J., Pycnogenol, French Maritime Pine Bark Extract, Encyclopedia of Dietary Supplements, pp. 545-553, (2005)

[10]

Duweler K.G., Rohdewald P., Urinary metabolites of French maritime pine bark extract in humans, Pharmazie, 55, pp. 364-368, (2000)

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