Epidemiology, etiology, detection, and treatment of autoantibody-associated congenital heart block in neonatal lupus

被引：67

作者：

Friedman D.M. ^{[1
]}

Rupel A. ^{[1
]}

Buyon J.P. ^{[1
]}

机构：

[1] New York University, School of Medicine, TCH-407, New York, NY 10016

来源：

Current Rheumatology Reports | 2007年 / 9卷 / 2期

基金：

美国国家卫生研究院;

关键词：

Complete Heart Block; Complete Atrioventricular Block; Neonatal Lupus; Conduction System Disease; Neonatal Lupus Erythematosus;

D O I：

10.1007/s11926-007-0003-4

中图分类号：

学科分类号：

摘要：

Neonatal lupus syndrome is a model of passively acquired autoimmunity in which the pregnant woman's serum contains specific antibodies to 52 or 60 kd SSA/Ro and/or 48 kd SSB/La, which cross the placenta and are associated with the development of congenital heart block in the fetus and/or a transient rash or various liver and blood cell abnormalities in the newborn. To date, congenital heart block is a permanent condition that entails significant morbidity and mortality, with nearly all affected infants requiring pacemakers and with an 80% cumulative probability of survival at 3 years of age. An intensive search is on for the specific etiopathophysiology and for new clinical tools to approach and treat this disease. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：101 / 108

页数：7

共 37 条

[1]

Buyon J.P., Clancy R.M., Neonatal lupus, Dubois' Lupus Erythematosus, pp. 1058-1080, (2006)

[2]

Buyon J.P., Hiebert R., Copel J., Et al., Autoimmune-associated congenital heart block: Demographics, mortality, morbidity, and recurrence rates obtained from a national neonatal lupus registry, J Am Coll Cardiol, 31, pp. 1658-1666, (1998)

[3]

Moak J.P., Barron K.S., Hougen T.J., Et al., Congenital heart block: Development of late-onset cardiomyopathy, a previously underappreciated sequela, J Am Coll Cardiol, 37, pp. 238-242, (2001)

[4]

Gladman G., Silverman E.D., Yuk-Law, Et al., Fetal echocardiographic screening of pregnancies of mothers with anti-Ro and/or anti-La antibodies, Am J Perinatol, 19, pp. 73-79, (2002)

[5]

Cimaz R., Spence D.L., Hornberger L., Silverman E.D., Incidence and spectrum of neonatal lupus erythematosus: A prospective study of infants born to mothers with anti-Ro autoantibodies, J Pediatr, 142, pp. 678-683, (2003)

[6]

Brucato A., Doria A., Frassi M., Et al., Pregnancy outcome in 100 women with autoimmune diseases and anti-Ro/SSA antibodies: A prospective controlled study, Lupus, 11, pp. 716-721, (2002)

[7]

Askanase A.D., Friedman D.M., Copel J., Et al., Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies, Lupus, 11, pp. 145-151, (2002)

[8]

Moak J.P., Barron K.S., Hougen T.J., Et al., Congenital heart block: Development of late-onset cardiomyopathy, a previously underappreciated sequela, J Am Coll Cardiol, 37, pp. 238-242, (2001)

[9]

Nield L.E., Silverman E.D., Taylor C.P., Et al., Maternal anti-Ro and anti-La antibody-associated endocardial fibroelastosis, Circulation, 105, pp. 843-848, (2002)

[10]

Nield L.E., Silverman E.D., Smallhorn J.F., Et al., Endocardial fibroelastosis associated with maternal anti-Ro and anti-La antibodies in the absence of atrioventricular block, J Am Coll Cardiol, 40, pp. 796-802, (2002)

← 1 2 3 4 →