The pathogenesis of cerebrovascular lesions in hypertensive rats

被引：19

作者：

Suzuki K. ^{[1
]}

Masawa N. ^{[1
]}

Takatama M. ^{[1
]}

机构：

[1] Division of Histopathology, Department of Laboratory Sciences, Gunma Univ. Sch. of Health Sciences, Maebashi, Gunma 371-8514

来源：

Medical Electron Microscopy | 2001年 / 34卷 / 4期

关键词：

Adhesion molecule; Cerebrovascular lesion; Cytokine; Hypertension; Leukocyte;

D O I：

10.1007/s007950100020

中图分类号：

学科分类号：

摘要：

In this study we investigated the pathogenesis of hypertensive cerebrovascular lesions by light microscopy, immunohistochemistry, scanning electron microscopy, and transmission electron microscopy. The brains of rats with experimentally induced hypertension exhibited severe edema and intracerebral hemorrhage. Light microscopy of the arteries showed severe medial lesions and the deposition of fibrinoid substance in the intima. Immunohistochemistry showed that intercellular adhesion molecule (ICAM)-1, platelet-endothelial cell adhesion molecule (PECAM)-1, interleukin (IL)-1α, IL-6, IL-8, and tumor necrosis factor (TNF)-α endothelial cell expression was upregulated. Scanning electron microscopy of these arteries revealed the adhesion of neutrophils, monocytes, and a few platelets to endothelial cells, and their invasion of endothelial cell junctions and opened junctions. Transmission electron microscopy showed neutrophil and monocyte adhesion to the endothelial cells and neutrophil and monocyte invasion of endothelial cell junctions, intimal deposition of fibrinoid substance, and severe medial cell injury. Intravenously injected horseradish peroxidase insudated from endothelial cell junctions and, via pinocytotic vesicles, into the subendothelial space. These findings suggest that hypertension activates endothelial cells to increase the expression of adhesion molecules and cytokines, and induces neutrophil and monocyte adhesion and migration, resulting in endothelial cell injury and increased permeability of endothelial cells, which results in hypertensive arterial disease.

引用

页码：230 / 239

页数：9

共 35 条

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