Distal Margin Requirements After Preoperative Chemoradiotherapy for Distal Rectal Carcinomas: Are ≤ 1 cm Distal Margins Sufficient?

被引:57
作者
Boris Kuvshinoff
Irfan Maghfoor
Brent Miedema
Mark Bryer
Steven Westgate
John Wilkes
David Ota
机构
[1] University of Missouri Ellis Fischel Cancer Center and Harry S. Truman VAMC,Departments of Surgery, Medical Oncology and Radiology
[2] Ellis Fischel Cancer Center,FACS
关键词
Rectal cancer; Distal margins; Radiation therapy; Chemotherapy; Sphincter preservation;
D O I
10.1007/s10434-001-0163-9
中图分类号
学科分类号
摘要
Background:Sphincter-sparing alternatives to abdominoperineal resection (APR) in the treatment of rectal cancer often are underused out of concern for inadequate distal margins and local failure. The present study addresses whether sphincter-sparing techniques with distal margins ≤ 1 cm adversely influence oncological outcome in patients given preoperative chemoradiotherapy.
引用
收藏
页码:163 / 169
页数:6
相关论文
共 98 条
[1]  
Meterissian S(1994)Patterns of residual disease after preoperative chemoradiation in ultrasound T3 rectal carcinoma Ann Surg Oncol 1 111-116
[2]  
Skibber J(1995)Preoperative chemoradiation downstages locally advanced ultrasound-staged rectal cancer Am J Surg 170 609-613
[3]  
Rich T(1998)Combined preoperative radiation and mitomycin/5-fluorouracil treatment for locally advanced rectal adenocarcinoma J Am Coll Surg 187 164-170
[4]  
Meade PG(1992)Enhancement of radiation-induced downstaging of rectal cancer by fluorouracil and high-dose leucovorin chemotherapy J Clin Oncol 10 79-84
[5]  
Blatchford GJ(1997)Preliminary results of pre-operative 5-fluorouracil(5-FU), low dose leucovorin, and concurrent radiation therapy for resectable T3 rectal cancer Dis Colon Rectum 40 515-522
[6]  
Thorson AG(1993)Mesorectal excision for rectal cancer Lancet 341 457-460
[7]  
Christensen MA(1995)Total mesorectal excision in the operative treatment of carcinoma of the rectum J Am Coll Surg 181 335-345
[8]  
Ternent CA(1996)Preoperative “chemoradiation” for stages II and III rectal carcinoma Arch Surg 131 514-519
[9]  
Burke SJ(1995)Preoperative infusional chemoradiation therapy for stage T3 rectal cancer Int J Radiat Oncol Biol Phys 32 1025-1029
[10]  
Percarpio BA(1995)Preoperative radiation and chemotherapy in the treatment of adenocarcinoma of the rectum Ann Surg 221 778-787