Novel heptamethine cyanine dyes with large stoke's shift for biological applications in the near infrared

被引:27
作者
Bertolino C.A. [1 ,2 ,3 ]
Caputo G. [1 ,3 ]
Barolo C. [1 ,3 ,4 ]
Viscardi G. [3 ,4 ]
Coluccia S. [1 ,3 ]
机构
[1] Dipartimento di Chimica IFM, Universit̀a di Torino, 10125 Torino
[2] ISI Foundation, Lagrange Project, 10133 Torino
[3] NIS Centre of Excellence, Universit̀a di Torino, 10125 Torino
[4] Dipartimento di Chimica Generale Ed Organica Applicata, Universit̀a di Torino, 10125 Torino
来源
J Fluoresc | 2006年 / 2卷 / 221-225期
关键词
Bioconjugation; Cyanine; Large Stokes; NIR dyes; Shift;
D O I
10.1007/s10895-006-0094-8
中图分类号
学科分类号
摘要
A series of novel functionalized, water-soluble, pH-unsensitive, highly photostable heptamethine cyanine dyes (HCDs) has been synthesized. The aim of the synthesis was to obtain novel effective probes for fluorescence detection in the near infrared. Synthesis and characterization of a special HCD with large Stokes' shift (>100 nm), bioconjugation to IgG and effect of pH upon the new structure are presented. © Springer Science+Business Media, Inc. 2006.
引用
收藏
页码:221 / 225
页数:4
相关论文
共 16 条
[1]  
Abdalla M.A., Bayer J., Radler J., Mullen K., Nucleosides, Nucleotides Nucleic Acids, 22, 5-8, pp. 1399-1401, (2003)
[2]  
Abdalla M.A., Bayer J., Radler J., Mullen K., Angew Chem Int Ed, 43, pp. 3967-3970, (2004)
[3]  
Intes X., Ripoll J., Chen Y., Nioka S., Yodh A.G., Chance B., Med Phys, 30, 6, pp. 1039-1047, (2003)
[4]  
Kim D.E., Schellingerhout D., Jaffer F.A., Weissleder R., Tung C.H., J Cereb Blood Flow Metab, 25, 2, pp. 226-233, (2005)
[5]  
Holzer W., Penzkofer A., Szeimies R.-M., Abels C., Landthaler M., J Photochem Photobiol B: Biol, 47, pp. 155-164, (1998)
[6]  
Wu S.P., Lee I., Ghoroghchian P.P., Frail P.R., Zheng G., Glickson J.D., Therien M.J., Bioconjug Chem, 16, 3, pp. 542-550, (2005)
[7]  
Weissleder R., Tung C., Mahmood U., Bogdanov A.J., Nat Biotechnol, 17, pp. 375-378, (1999)
[8]  
Strekowski L., Lipowska M., Patonay G., J Org Chem, 57, pp. 4578-4580, (1992)
[9]  
Lim J.H., Przhonska O.V., Khodja S., Yang S., Ross T.S., Bondar M.V., Slominsky Y.L., Chem Phys, 245, pp. 79-97, (1999)
[10]  
Ellis A.L., Christian Mason J., Lee H.-W., Strekowski L., Patonay G., Choi H., Yang J.J., Talanta, 56, pp. 1099-1107, (2002)