Increased blood-brain barrier permeability in neuro-asymptomatic HIV-1-infected individuals - Correlation with cerebrospinal fluid HIV-1 RNA and neopterin levels

被引：58

作者：

Andersson L.M. ^{[1
]}

Hagberg L. ^{[1
]}

Fuchs D. ^{[1
]}

Svennerholm B. ^{[1
]}

Gisslén M. ^{[1
]}

机构：

[1] Department of Infectious Diseases, Sahlgrenska University Hospital, Institute of Internal Medicine

来源：

Journal of NeuroVirology | 2001年 / 7卷 / 6期

关键词：

Albumin ratio; Blood-brain barrier; Cerebrospinal fluid; HIV-1; RNA; Neopterin;

D O I：

10.1080/135502801753248123

中图分类号：

学科分类号：

摘要：

The objective of this study was to assess the frequency of blood-brain barrier (BBB) impairment, as measured by the albumin ratio, in neuro-asymptomatic HIV-1-infected individuals without antiretroviral treatment and the correlation between BBB disruption and intrathecal immune activation and HIV-1 RNA levels. Serum and cerebrospinal fluid (CSF) albumin, neopterin, and HIV-1 RNA levels were analysed in 110 neuro-asymptomatic HIV-1-infected individuals at different stages of disease; 63 classified as CDC A, 25 as CDC B, and 22 as CDC C. Increased BBB permeability was found in 17 of 110 (15%) of HIV-1-infected individuals. This proportion was sustained throughout the CDC stages. The albumin ratio was correlated with the CSF neopterin levels (rs=0.36, P <0.001), the serum neopterin levels (rs=0.37, P <0.001), and the CSF HIV-1 RNA levels (rs=0.26, P <0.01), but not with the plasma HIV-1 RNA levels. The correlations between the albumin ratio and the CSF and serum neopterin concentrations and the CSF HIV-1 RNA levels indicate that immune activation and, possibly, intrathecal HIV-1 virus replication are important factors associated with increased BBB permeability in HIV-1 infection.

引用

页码：542 / 547

页数：5

共 38 条

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