Diffusion tensor imaging of frontal lobe white matter tracts in schizophrenia

被引：71

作者：

Buchsbaum M.S. ^{[1
]}

Schoenknecht P. ^{[2
]}

Torosjan Y. ^{[1
]}

Newmark R. ^{[1
]}

Chu K.-W. ^{[1
]}

Mitelman S. ^{[1
]}

Brickman A.M. ^{[3
]}

Shihabuddin L. ^{[1
]}

Haznedar M.M. ^{[1
]}

Hazlett E.A. ^{[1
]}

Ahmed S. ^{[1
]}

Tang C. ^{[4
]}

机构：

[1] Department of Psychiatry, Mount Sinai School of Medicine, New York, NY

[2] Department of Psychiatry, University Hospital Heidelberg, Ruprecht-Karls-University, Heidelberg

[3] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY

[4] Department of Radiology, Mount Sinai School of Medicine, New York, NY

来源：

Annals of General Psychiatry | / 5卷 / 1期

关键词：

Schizophrenia; Prefrontal Cortex; Fractional Anisotropy; Diffusion Tensor Image; Diffusion Tensor;

D O I：

10.1186/1744-859X-5-19

中图分类号：

学科分类号：

摘要：

We acquired diffusion tensor and structural MRI images on 103 patients with schizophrenia and 41 age-matched normal controls. The vector data was used to trace tracts from a region of interest in the anterior limb of the internal capsule to the prefrontal cortex Patients with schizophrenia had tract paths that were significantly shorter in length from the center of internal capsule to prefrontal white matter. These tracts, the anterior thalamic radiations, are important in frontal-striatal-thalamic pathways. These results are consistent with findings of smaller size of the anterior limb of the internal capsule in patients with schizophrenia, diffusion tensor anisotropy decreases in frontal white matter in schizophrenia and hypothesized disruption of the frontal-striatal-thalamic pathway system. © 2006 Buchsbaum et al; licensee BioMed Central Ltd.

引用

共 58 条

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