Cognitive reserve: Implications for diagnosis and prevention of Alzheimer's disease

被引：190

作者：

Scarmeas N. ^{[1
]}

Stern Y. ^{[1
]}

机构：

[1] Columbia Presbyterian Medical Center, New York, NY 10032

来源：

Current Neurology and Neuroscience Reports | 2004年 / 4卷 / 5期

关键词：

Dementia; Cognitive Reserve; Epidemiologic Catchment Area Study; High Cognitive Reserve; Kungsholmen Project;

D O I：

10.1007/s11910-004-0084-7

中图分类号：

学科分类号：

摘要：

Epidemiologic evidence suggests that higher occupational attainment and education, as well as increased participation in intellectual, social, and physical aspects of daily life, are associated with slower cognitive decline in healthy elderly and may reduce the risk of incident Alzheimer's disease (AD). There is also evidence from structural and functional imaging studies that patients with such life experiences can tolerate more AD pathology before showing signs of clinical dementia. It has been hypothesized that such aspects of life experience may result in functionally more efficient cognitive networks and, therefore, provide a cognitive reserve that delays the onset of clinical manifestations of dementia. In this article, we review some of the relevant literature of the noted associations between markers of cognitive reserve and AD and discuss the possible mechanisms that may explain these associations. Copyright © 2004 by Current Science Inc.

引用

页码：374 / 380

页数：6

共 100 条

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