Recent findings in ABO-incompatible kidney transplantation: Classification and therapeutic strategy for acute antibody-mediated rejection due to ABO-blood-group-related antigens during the critical period preceding the establishment of accommodation

被引：65

作者：

Takahashi K. ^{[1
]}

机构：

[1] Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata 951-8510

来源：

Clinical and Experimental Nephrology | 2007年 / 11卷 / 2期

关键词：

ABO-blood-group antigens; ABO-blood-group-associated antigen; ABO-blood-group-related antigens; ABO-incompatible kidney transplantation; Accommodation; Antibody-mediated rejection;

D O I：

10.1007/s10157-007-0461-z

中图分类号：

学科分类号：

摘要：

In Japan, ABO-incompatible kidney transplantation has been performed in more than 1000 patients since 1989, and recently accounts for about 18% of all living donor kidney transplants. As for outcomes, since 2001 the 1-year and 3-year graft survival rates have increased to 96% and 94%, respectively, which are similar to those in ABO-compatible transplantation. These improved outcomes are attributed to a clearer understanding of the mechanisms underlying accommodation and acute antibody-mediated rejection, permitting the development of new therapeutic strategies. This review classifies and discusses the clinical significance of acute antibody-mediated rejection due to ABO-blood-group- related antigens during the critical period preceding the establishment of accommodation. © 2007 Japanese Society of Nephrology.

引用

页码：128 / 141

页数：13

共 50 条

[1]

Takahashi K., Accommodation in ABO-incompatible kidney transplantation: Why do kidney grafts survive?, Transplant Proc, SUPPL. 2S, pp. 193-196, (2004)

[2]

Takahashi K., Accommodation in ABO-incompatible Kidney Transplantation, pp. 1-209, (2004)

[3]

Takahashi K., A new concept of accommodation in ABO-incompatible kidney transplantation, Clin Transplant, 19, pp. 76-85, (2005)

[4]

Takahashi K., Saito K., Takahara S., Okuyama A., Tanbe K., Toma H., Et al., Japanese ABO-Incompatible Kidney Transplantation Committee. Excellent long-term outcome of ABO-incompatible living donor kidney transplantation in Japan, Am J Transplant, 4, pp. 1089-96, (2004)

[5]

Takahashi K., Saito K., Japanese ABO-Incompatible Kidney Transplantation Committee. Present status of ABO-incompatible kidney transplantation in Japan, Xenotransplant, 13, pp. 118-22, (2006)

[6]

Takahashi K., Takahashi K., A new immunosuppressive therapy in ABO-incompatible kidney transplantation based on a new concept of accommodation, ABO-incompatible Organ Transplantation from Japan, pp. 73-87, (2006)

[7]

Saito K., Nakagawa Y., Suwa M., Kumagai N., Tanikawa T., Takahashi K., Et al., Pinpoint targeted immunosuppression: Anti-CD20/MMF desensitization with anti-CD25 in successful ABO-incompatible kidney transplantation without splenectomy, Xenotransplant, 13, pp. 111-7, (2006)

[8]

Morris P.J., Monaco A.P., Book review. Accommodation in ABO-incompatible kidney transplantation, Transplantation, 81, (2006)

[9]

Takahashi K., Takahashi K., A case of rebound following pretransplant antibody removal, with subsequent graft loss due to humoral rejection, ABO-incompatible Kidney Transplantation, (2001)

[10]

Takahashi K., Takahashi K., If graft loss occurs, Accommodation in ABO-incompatible Kidney Transplantation, (2004)

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