Low birth weight and preterm births: Etiologic fraction attributable to prenatal drug exposure

被引：151

作者：

Bada H.S. ^{[1
]}

Das A. ^{[2
]}

Bauer C.R. ^{[3
]}

Shankaran S. ^{[4
]}

Lester B.M. ^{[5
]}

Gard C.C. ^{[2
]}

Wright L.L. ^{[6
]}

LaGasse L. ^{[5
]}

Higgins R. ^{[6
]}

机构：

[1] Department of Pediatrics, College of Medicine, University of Kentucky, Lexington, KY

[2] Research Triangle Institute International, Research Triangle Park, NC

[3] Department of Pediatrics, University of Miami, Miami, FL

[4] Department of Pediatrics, Wayne State University, Detroit, MI

[5] Department of Pediatrics, Brown University Medical School, Providence, RI

[6] National Institute of Child Health and Human Development, Bethesda, MD

来源：

Journal of Perinatology | 2005年 / 25卷 / 10期

关键词：

D O I：

10.1038/sj.jp.7211378

中图分类号：

学科分类号：

摘要：

Objectives: To determine the factors that would increase the likelihood of outcomes: low birth weight (LBW), preterm births and intrauterine growth restriction (IUGR). Study design: Secondary data analysis from a multi-center study. Risk factors for each outcome were derived from logistic regression models. Odds ratios (OR), 95% confidence intervals, and population-attributable risk proportions (PAR%) were estimated. Results: Prenatal cocaine exposure increased the likelihood of LBW (OR: 3.59), prematurity (OR: 1.25), and IUGR (OR: 2.24). Tobacco, but not marijuana, significantly influenced these outcomes. Alcohol had an effect on LBW and IUGR. Etiologic fractions (PAR%) attributable to tobacco for LBW, prematurity, and IUGR were 5.57, 3.66, and 13.79%, respectively. With additional drug exposure including cocaine, estimated summary PAR% increased to 7.20% (LBW), 5.68% (prematurity), and 17.96% (IUGR). Conclusion: Disease burden for each outcome increases with each added drug exposure; however, etiologic fraction attributable to tobacco is greater than for cocaine. © 2005 Nature Publishing Group. All rights reserved.

引用

页码：631 / 637

页数：6

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