Expression of neuronal plasticity markers in hypoglycemia induced brain injury

被引：10

作者：

Pawan Singh

Pawan Kumar Heera

Gurcharan Kaur

机构：

[1] Guru Nank Dev University,Neurochemistry and Neuroendocrinology Laboratory, Department of Biotechnology

来源：

Molecular and Cellular Biochemistry | 2003年 / 247卷

关键词：

growth-associated protein-43; glial fibrilliary acidic protein; neural cell adhesion molecule; hypoglycemia; insulin;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The expression of neuroplasticity markers was analyzed in four brain regions, namely cerebral hemispheres (CH), cerebellum (CB), brain stem (BS) and diencephalon (DC) from insulin-induced hypoglycemic young adult rats. Significant decrease in neural cell adhesion molecule (NCAM) isoforms and growth-associated protein-43 (GAP-43) was observed following hypoglycemic injury from majority of brain regions studied. The glial fibrillary acidic protein (GFAP) level increased significantly in cerebral hemispheres and diencephalon regions, whereas, synaptophysin level increased in cerebellum, brain stem and diencephalon regions. The selective downregulation of the neuronal plasticity marker proteins (GAP-43 and NCAM), and enhanced expression of GFAP and synaptophysin suggests that in acute hypoglycemia, mechanisms other than energy failure may also contribute to neuronal cell damage in the brain.

引用

页码：69 / 74

页数：5

共 128 条

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