Colloidal metallic gold is not bio-inert

被引：55

作者：

Brown C.L. ^{[1
]}

Whitehouse M.W. ^{[1
]}

Tiekink E.R.T. ^{[1
]}

Bushell G.R. ^{[1
]}

机构：

[1] Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Science, Griffith University, Brisbane

来源：

Inflammopharmacology | 2008年 / 16卷 / 3期

关键词：

Gold Nanoparticles; Colloidal Gold; Pristane; Metallic Gold; Dark Agouti;

D O I：

10.1007/s10787-007-0017-6

中图分类号：

学科分类号：

摘要：

Metallic gold (Au°) is a likely biotransformation product of monovalent gold, Au(I) whenever it is dissociated from in vivo ligands, Au° being formed either by bioreduction or by spontaneous dismutation (with co-production of trivalent gold). This review discusses the preparation and some biologically relevant properties of colloidal metallic gold (CMG) in its nano-particulate form. Tyndall's purple, a well characterised preparation of CMG, shows potent anti-arthritic activity in rats, approximately 103 times that of sodium aurothiomalate (Myocrysin). Even more remarkable is its broader spectrum of action in rats compared to this classic DMARD. © 2008 Springer.

引用

页码：133 / 137

页数：4

共 51 条

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