Rectal cancer in young Indians-Are these cancers different compared to their older counterparts?

被引：18

作者：

Barreto S.G. ^{[2
]}

Chaubal G.N. ^{[2
]}

Talole S. ^{[1
]}

DeSouza A. ^{[2
]}

Suradkar K. ^{[2
]}

Gaikwad V. ^{[2
]}

Goel M. ^{[2
]}

Shrikhande S.V. ^{[2
]}

机构：

[1] Department of Biostatistics and Epidemiology, Tata Memorial Hospital, Mumbai, 400 012, Parel

[2] Department of Gastrointestinal and Hepatopancreatobiliary Surgical Oncology, Tata Memorial Hospital, Mumbai, 400 012, Parel

来源：

Indian Journal of Gastroenterology | 2014年 / 33卷 / 2期

关键词：

Mortality; Outcomes; Surgery;

D O I：

10.1007/s12664-013-0396-0

中图分类号：

学科分类号：

摘要：

Background: The incidence of rectal cancer in young Indians is increasing. Recent evidence suggests a probable existence of noncanonical tumorigenesis pathways in early-onset colorectal cancer patients in India. The aim of the study was to evaluate rectal cancer outcomes in patients ≤40 years with those >40 years. Methods: An analysis of a prospective database of surgically treated rectal cancer patients ≤40 years (group 1) and those >40 years (group 2) over 2 years was performed. Clinicopathological features, perioperative outcomes, and disease-free survival (DFS) were analyzed. Results: Of the 512 patients with colorectal cancer treated surgically, 237 patients (group 1-57 patients; group 2-180 patients) were diagnosed with nonmetastatic rectal adenocarcinoma. Patients in group 1 were more likely to present with locally advanced (stage III) disease (p < 0.005) resulting in a higher proportion of them receiving neoadjuvant chemoradiotherapy (NACT-RT). There was no difference in morbidity and mortality between the two groups. Younger patients had a significantly higher median total and positive lymph node yield (p < 0.003). Patients in group 1 had a significantly lower overall DFS (p < 0.005). Stage-specific DFS also demonstrated a significantly lower trend in stage III patients in group 1. Conclusions: Young rectal cancer patients in India tended to present more frequently with locally advanced tumors resulting in a higher proportion being treated with NACT-RT. Stapled rectal anastomoses could be performed safely in young patients even after NACT-RT. The significantly poorer DFS in young Indian patients with stage III disease was a novel finding and merits further investigation into tumor biology. © 2013 Indian Society of Gastroenterology.

引用

页码：146 / 150

页数：4

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