Effects of glaucoma drugs on ocular hemodynamics in normal tension glaucoma: A randomized trial comparing bimatoprost and latanoprost with dorzolamide [ISRCTN18873428]

被引：44

作者：

Zeitz O. ^{[1
]}

Matthiessen E.T. ^{[1
]}

Reuss J. ^{[1
]}

Wiermann A. ^{[1
]}

Wagenfeld L. ^{[1
]}

Galambos P. ^{[1
]}

Richard G. ^{[1
]}

Klemm M. ^{[1
]}

机构：

[1] Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Augenheilkunde, D- 20246 Hamburg

来源：

BMC Ophthalmology | / 5卷 / 1期

关键词：

Glaucoma; Blood Flow Velocity; Optic Nerve Head; Latanoprost; Bimatoprost;

D O I：

10.1186/1471-2415-5-6

中图分类号：

学科分类号：

摘要：

Background: Reduced choroidal perfusion is hypothesized to play a role in the pathogenesis of normal tension glaucoma. Thus the impact of antiglaucomatous eye drops on ocular perfusion has been the focus of recent research and the subject of intensive investigations. The present study investigates whether topically applied latanoprost or bimatoprost influence ocular perfusion in patients with normal tension glaucoma and compares these effects with that changes detected after the treatment with dorzolamide. Methods: Ocular hemodynamics were assessed by color Doppler imaging (CDI) shortly before and after a one-month treatment with either latanoprost, bimatoprost or dorzolamide. Primary end-points of the study were peak systolic and end-diastolic blood flow velocities in the short posterior ciliary artery (SPCA) under the new therapy. Intraocular pressure (IOP) and additional perfusion parameters in the SPCA and other retrobulbar vessels were tracked as observational parameters. n = 42 patients with normal tension glaucoma were enrolled in the study. Results: Systolic and diastolic blood flow velocities in the SPCA showed no significant alteration after the treatment with latanoprost or bimatoprost. Dorzolamide lead to increase of peak systolic velocity. IOP was reduced by all three agents in a range reported in the literature. Conclusion: Topically applied latanoprost and bimatoprost act in a hemodynamically neutral manner and have the capability to lower IOP even in patients with normal tension glaucoma and low initial IOP level. Dorzolamide accelerates blood flow in systole. None of the tested compounds has a negative impact on hemodynamics in the short posterior ciliary arteries. © 2005 Zeitz et al; licensee BioMed Central Ltd.

引用

共 46 条

[1]

Goldmann H., Open-angle glaucoma, Br J Ophthalmol, 56, pp. 242-248, (1972)

[2]

Sommer A., Tielsch J.M., Katz J., Quigley H.A., Gottsch J.D., Javitt J., Singh K., Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans. The Baltimore Eye Survey, Arch Ophthalmol, 109, pp. 1090-1095, (1991)

[3]

Pillunat L.E., Stodtmeister R., Marquardt R., Mattern A., Ocular perfusion pressures in different types of glaucoma, Int Ophthalmol, 13, pp. 37-42, (1989)

[4]

Klingmuller V., Schmidt K.G., Von Ruckmann A., Koch B., Stein A., Doppler sonography of the short posterior ciliary artery in patients with primary open angle glaucoma, Ultraschall Med, 21, pp. 32-37, (2000)

[5]

Maumenee A.E., Causes of optic nerve damage in glaucoma. Robert N. Shaffer lecture, Ophthalmology, 90, pp. 741-752, (1983)

[6]

Schmidt K.G., Ruckmann A.V., Mittag T.W., Hessemer V., Pillunat L.E., Reduced ocular pulse amplitude in low tension glaucoma is independent of vasospasm, Eye, 11, pp. 485-488, (1997)

[7]

Schumann J., Orgul S., Gugleta K., Dubler B., Flammer J., Interocular difference in progression of glaucoma correlates with interocular differences in retrobulbar circulation, Am J Ophthalmol, 129, pp. 728-733, (2000)

[8]

Boehm A.G., Pillunat L.E., Koeller U., Katz B., Schicketanz C., Klemm M., Richard G., Regional distribution of optic nerve head blood flow, Graefes Arch Clin Exp Ophthalmol, 237, pp. 484-488, (1999)

[9]

The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma, Am J Ophthalmol, 126, pp. 498-505, (1998)

[10]

Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures, Am J Ophthalmol, 126, pp. 487-497, (1998)

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