Intensity modulated radiation therapy and proton radiotherapy for non-small cell lung cancer

被引：27

作者：

Chang J.Y. ^{[1
]}

Liu H. ^{[1
]}

Komaki R. ^{[1
]}

机构：

[1] Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030

来源：

Current Oncology Reports | 2005年 / 7卷 / 4期

关键词：

Radiat Oncol Biol Phys; Intensity Modulate Radiation Therapy; Proton Radiotherapy; Tumor Motion; Internal Target Volume;

D O I：

10.1007/s11912-005-0047-4

中图分类号：

学科分类号：

摘要：

Local failure of non-small-cell lung cancer (NSCLC) radiotherapy may cause continuous tumor seeding and death. Radiotherapy dose escalation has been shown to improve local control and survival. However, the toxicities associated with dose escalation are significant and limit the potential of dose escalation. Intensity modulated radiotherapy (IMRT) may have the potential to improve the therapeutic ratio for photon treatment of lung cancer by sparing surrounding normal tissues. However, low-dose exposure to normal lung and organ motion is a major concern. We have conducted several studies to address these issues and started clinical studies to evaluate the potential benefit of IMRT in patients with NSCLC. Proton radiotherapy may have greater potential to spare normal tissue and allow for further dose escalation and acceleration. We are conducting preclinical and clinical studies for imaging-guided proton radiotherapy in NSCLC. In this paper, we discuss the preliminary data, IMRT treatment guidelines, and ongoing studies for proton therapy in NSCLC. Copyright © 2005 by Current Science Inc.

引用

页码：255 / 259

页数：4

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