丙戊酸治疗神经退行性疾病的研究进展

被引：1

作者：

余磊 ^{[1
,2
,3
]}

刘新光 ^{[1
,2
,3
]}

机构：

[1] 广东医学院衰老研究所

[2] 广东省医学分子诊断重点实验室

[3] 广东医学院生物化学与分子生物学研究所

来源：

国际老年医学杂志 | 2014年 / 35卷 / 03期

基金：

广东省自然科学基金;

关键词：

丙戊酸; 神经保护; 神经退行性疾病; 阿尔茨海默病; 脊髓性肌萎缩症;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

100204 [神经病学];

摘要：

神经退行性疾病是大脑和脊髓的神经细胞或其髓鞘的丧失所致的一类疾病,包括数十种,严重影响着人类的健康和生活质量。但是,目前可用于治疗神经退行性疾病的药物较少。丙戊酸(valproic acid,VPA)在基因转录和表达方面具有重要作用,并可通过多种机制发挥神经保护作用,因此,VPA成为近年开发治疗神经退变性疾病的热点。本文综述丙戊酸的神经保护作用,并以阿尔茨海默病和脊髓性肌萎缩症为代表介绍近年VPA治疗神经退行性疾病的研究进展。

引用

页码：107 / 110

页数：4

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