胆汁淤积性肝病药物治疗研究进展

被引：3

作者：

葛启超

陆伦根

机构：

[1] 上海交通大学附属第一人民医院消化科

来源：

肝脏 | 2023年 / 28卷 / 11期

关键词：

胆汁淤积性肝病; 胆汁酸; 核受体; 肠肝循环; 治疗;

D O I：

10.14000/j.cnki.issn.1008-1704.2023.11.001

中图分类号：

R575 [肝及胆疾病];

学科分类号：

100201 [内科学];

摘要：

胆汁淤积性肝病是以胆汁在肝内蓄积导致肝胆组织损伤和功能障碍为特征的疾病。核受体(NR)是调控包括肝脂质代谢、葡萄糖代谢、能量消耗和胆汁酸(BA)体内平衡的关键转录因子，而这些过程的失调是胆汁淤积以及脂肪性肝病的重要致病机制。既往基于NR已经开发了靶向的高亲和力治疗配体，包括法尼醇-X受体(FXR)和过氧化物酶体增殖物激活受体(PPARs)的激动剂。除此之外，成纤维细胞生长因子19(FXR-19)的类似物，以及肝细胞和肠细胞的BA摄取抑制剂也对胆汁淤积性肝病有良好的治疗潜力。因此，本文就近年来胆汁淤积性肝病的靶向药物研究做一综述。

引用

页码：1261 / 1263

页数：3

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