不同亚型肠易激综合征患者肠黏膜屏障指标变化的比较

被引：5

作者：

吴焱

樊丽兰

董守权

王红玲

机构：

[1] 武汉大学中南医院消化内科/湖北省肠病临床研究中心/湖北省肠病重点实验室

来源：

武汉大学学报(医学版) | 2024年 / 45卷 / 03期

关键词：

肠易激综合征; 肠黏膜屏障; 二胺氧化酶; D-乳酸; 细菌内毒素;

D O I：

暂无

中图分类号：

R574.4 [肠道功能紊乱];

学科分类号：

100201 [内科学];

摘要：

目的：探讨罗马Ⅳ标准下不同亚型肠易激综合征（IBS）患者肠黏膜屏障功能相关指标水平的变化及其与IBS亚型的关联。方法：纳入IBS患者77例及同时期体检的正常对照71例作为研究对象,根据Bristol粪便性状，将IBS患者分为3个亚组：腹泻型（IBS-D）31例，便秘型（IBS-C）20例、混合型（IBS-M）26例。比较患病组与健康对照组之间二胺氧化酶（DAO）、D-乳酸、细菌内毒素水平的差异及其与不同亚型IBS的关联，并用受试者工作特征（ROC）曲线分析上述指标预测IBS-D的敏感度与特异度。结果：与健康对照相比，IBS患者血清DAO、D-乳酸、细菌内毒素水平均显著增高(P<0.05)；在3种不同的IBS亚型中，IBS-D组血清DAO、D-乳酸、细菌内毒素水平较IBS-C组显著增高(P<0.05)，而D-乳酸、细菌内毒素水平较IBS-M组也显著增高(P<0.05);ROC曲线显示DAO、D-乳酸、细菌内毒素的曲线下面积（AUC）分别为0.813、0.834、0.865，而当三项指标作为联合预测因子时，AUC为0.898，大于使用单项指标作为预测因子的AUC。结论：IBS患者存在肠黏膜屏障功能障碍，其中肠屏损伤在IBS-D的发病中起着更为重要的作用，且DAO、D-乳酸及细菌内毒素对于临床上预测IBS-D发病具有良好的诊断价值。

引用

页数：6

共 11 条

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