Scientific Opinion on the substantiation of a health claim related to barley beta-glucans and lowering of blood cholesterol and reduced risk of (coronary) heart disease pursuant to Article 14 of Regulation (EC) No 1924/2006

被引：25

作者：

Agostoni, Carlo ^{[1
]}

Bresson, Jean-Louis ^{[1
]}

Fairweather-Tait, Susan ^{[1
]}

Flynn, Albert ^{[1
]}

Golly, Ines ^{[1
]}

Korhonen, Hannu ^{[1
]}

Lagiou, Pagona ^{[1
]}

Lovik, Martinus ^{[1
]}

Marchelli, Rosangela ^{[1
]}

Martin, Ambroise ^{[1
]}

Moseley, Bevan ^{[1
]}

Neuhauser-Berthold, Monika ^{[1
]}

Przyrembel, Hildegard ^{[1
]}

Salminen, Seppo ^{[1
]}

Sanz, Yolanda ^{[1
]}

Strain, Sean ^{[1
]}

Strobel, Stephan ^{[1
]}

Tetens, Inge ^{[1
]}

Tome, Daniel ^{[1
]}

van Loveren, Hendrik ^{[1
]}

Verhagen, Hans ^{[1
]}

机构：

[1] EFSA, Parma, Italy

来源：

EFSA JOURNAL | 2011年 / 9卷 / 12期

关键词：

Barley beta-glucans; fibre; blood cholesterol; LDL-cholesterol; health claims;

D O I：

10.2903/j.efsa.2011.2471

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Following an application from Valens Int. d.o.o. submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of Slovenia, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to barley beta-glucans and lowering of blood cholesterol and reduced risk of (coronary) heart disease, referring to disease risk reduction and including a request for the protection of proprietary data. The food constituent that is the subject of the health claim, barley beta-glucans, is sufficiently characterised. Lowering blood LDL-cholesterol concentration is a beneficial physiological effect by decreasing the risk of coronary heart disease. The applicant identified a total of eight references as being pertinent to the health claim. These references included two meta-analyses and six human studies. In weighing the evidence, the Panel took into account that one meta-analysis including 11 RCTs, and one additional RCT, which investigated the effects of barley beta-glucans at doses of at least 3 g/day showed a decrease in total and LDL-cholesterol concentrations in both normo-and hypercholesterolaemic subjects, and that there is evidence supporting the biological plausibility of the mechanism of the effect. The Panel concludes that a cause and effect relationship has been established between the consumption of barley beta-glucans and lowering of blood LDL-cholesterol concentrations. The following wording reflects the scientific evidence: "Barley beta-glucans have been shown to lower/reduce blood cholesterol. High cholesterol is a risk factor in the development of coronary heart disease". At least 3 g of barley beta-glucans should be consumed per day in order to obtain the claimed effect. The target population is adults who want to lower their blood cholesterol concentrations. (C) European Food Safety Authority, 2011

引用

页数：13

共 28 条

[1] β-glucan from barley and its lipid-lowering capacity: a meta-analysis of randomized, controlled trials [J].