MOLECULAR DESIGN OF NOVEL PGI(2) AGONISTS WITHOUT PG SKELETON .4.

被引：15

作者：

HAMANAKA, N

TAKAHASHI, K

NAGAO, Y

TORISU, K

TOKUMOTO, H

KONDO, K

机构：

[1] Minase Research Institute, Ono Pharmaceutical Co., Ltd. Shimamoto, Mishima, Osaka

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 10期

关键词：

D O I：

10.1016/0960-894X(95)00170-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological evaluation of a novel series of di or tetrahydronaphthalene-5-oxyacetic acid derivatives with the 4-benzhydryl pyrazole group is described. Among these compounds, 7 has been identified as a highly potent PGI(2) agonist with an exceptionally long in vivo duration of action.

引用

页码：1083 / 1086

页数：4