4-3(5)-PYRAZOLYLPYRIDINIUM SALTS - A NEW CLASS OF HYPOGLYCEMIC AGENTS

被引：63

作者：

BAUER, VJ

DALALIAN, HP

FANSHAWE, WJ

SAFIR, SR

TOCUS, EC

BOSHART, CR

机构：

[1] Experimental Therapeutics Research Section, Lederle Laboratories, Division of American Cyanamid Company, Pearl River

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1968年 / 11卷 / 05期

关键词：

D O I：

10.1021/jm00311a015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-[3(5)pyrazolyl]pyridimum salts has been synthesized. Many of these compounds display interesting hypoglycemic activity in alloxan-diabetic mice; a structure-activity relationship is derived. © 1968, American Chemical Society. All rights reserved.

引用

页码：981 / &

共 8 条

[1] SYNTHETISCHE REAKTIONEN VON DIMETHYLFORMAMID .16. FOMYLIERUNG VON GAMMA-PICOLIN
ARNOLD, Z
[J]. COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1963, 28 (04) : 863 - &
[2] BAUER VJ, 1968, J MED CHEM, V11, P984, DOI 10.1021/jm00311a016
[3] FABBRINI L, 1954, Farmaco Sci, V9, P603
[4] FATUTTA S, 1958, GAZZ CHIM ITAL, V88, P89
[5] 4-nitro-5-(3-pyridyl)pyrazole, a new oxidation product of nicotine Part III Confirmatory synthetical experiments
Gough, GAC
King, H
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1933, : 350 - 351
[6] Hoffman WS, 1937, J BIOL CHEM, V120, P51
[7] CHEMOTHERAPIE DER EXPERIMENTELLEN TUBERKULOSE .2. KERNSUBSTITUIERTE ISONICOTINSAUREHYDRAZIDE
ISLER, O
GUTMANN, H
STRAUB, O
FUST, B
BOHNI, E
STUDER, A
[J]. HELVETICA CHIMICA ACTA, 1955, 38 (04) : 1033 - 1046
[8] WAGNER HA, 1965, Patent No. 3200128

← 1 →