IRREVERSIBLE ENZYME INHIBITORS .68. 2-AMINO-5-(P-BROMOACETAMIDOPHENOXYPROPYL)-6-PHENYL-4-PYRIMIDINOL AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR OF DIHYDROFOLIC REDUCTASE

被引：17

作者：

BAKER, BR

SHAPIRO, HS

机构：

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1966年 / 55卷 / 12期

关键词：

D O I：

10.1002/jps.2600551219

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1422 / &

共 20 条

[1]

BAKER BH, TO BE PUBLISHED

[2] NON-CLASSICAL ANTIMETABOLITES .6. 4-(IODOACETAMIDO)-SALICYLIC ACID, AN EXO-ALKYLATING IRREVERSIBLE INHIBITOR [J].

BAKER, BR ;

LEE, WW ;

TONG, E .

JOURNAL OF THEORETICAL BIOLOGY, 1962, 3 (03) :459-&

[3] POTENTIAL ANTICANCER AGENTS .66. NON-CLASSICAL ANTIMETABOLITES .3. 4-(IODOACETAMIDO)-SALICYLIC ACID, AN EXO-ALKYLATING IRREVERSIBLE INHIBITOR OF GLUTAMIC DEHYDROGENASE [J].

BAKER, BR ;

LEE, WW ;

ROSS, LO ;

TONG, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1961, 83 (17) :3713-&

[4] FACTORS IN DESIGN OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS [J].

BAKER, BR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (04) :347-&

[5] ANALOGS OF TETRAHYDROFOLIC ACID .27. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE BY 2-AMINO-4,6-DISUBSTITUTED-5-ALKYLPYRIMIDINES AND 1-ALKYL-4,6-DIAMINO-1,2-DIHYDRO-S-TRIAZINES [J].

BAKER, BR ;

HO, BT ;

SANTI, DV .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (10) :1415-&

[6]

BAKER BR, 1966, J PHARM SCI, V55, P295

[7] ANALOGS OF TETRAHYDROFOLIC ACID .26. SYNTHESIS OF SOME 5-ARYL AND 5-ARALKYL PYRIMIDINE-6-CARBOXYLIC ACIDS AND THEIR EFFECT ON DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE [J].

BAKER, BR ;

JORDAAN, JH .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (02) :162-&

[8] ANALOGS OF TETRAHYDROFOLIC ACID .9. SYNTHESIS OF N-[1-(2-AMINO-4-HYDROXY-6-PHENYL-5-PYRIMIDYL)-3-PROPYL]-P-AMINOBENZOYL-L-GLUTAMIC ACID, A NONCLASSICAL INHIBITOR OF SOME FOLIC COFACTOR AREA ENZYMES [J].

BAKER, BR ;

SHAPIRO, HS .

JOURNAL OF MEDICINAL CHEMISTRY, 1963, 6 (06) :664-&

[9] ANALOGS OF TETRAHYDROFOLIC ACID .29. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE .2. ON MODE OF PHENYL BINDING OF 1-ARYL-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINES [J].

BAKER, BR ;

HO, BT .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (04) :335-&

[10]

BAKER BR, 1966, J PHARM SCI, V55, P1417, DOI 10.1002/jps.2600551218

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