DIFFERENTIATING AGENTS IN THE TREATMENT OF LEUKEMIA AND MYELODYSPLASTIC SYNDROMES

被引：9

作者：

DEGOS, L

机构：

[1] Hôpital Saint Louis, Paris 10e, 1, av. Claude Vellefaux

来源：

LEUKEMIA RESEARCH | 1990年 / 14卷 / 08期

关键词：

all-trans retinoic acid; Differentiation therapy; interferon alpha; leukemia; low dose Ara-C;

D O I：

10.1016/0145-2126(90)90103-G

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Differentiation therapies try to change the malignant cell in order to acquire a more mature or normal phenotype. Various ways were tested in leukemia: suppression the proliferative pressure by low dose Ara-C, enhancement of the differentiation by retinoic acid derivatives or by differentiation factors, and modulation of the cell metabolism interrupting an autocrine loop (a growth factor and its receptor). The treatment is given continuously at small doses, during a long period of time. In all these cases it seems necessary to tailor the differentiation therapy to each category of leukemia. © 1990.

引用

页码：731 / 733

页数：3

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