LOCALIZATION OF THE MRX3 GENE FOR NONSPECIFIC X-LINKED MENTAL-RETARDATION

被引：49

作者：

GEDEON, A ^{[1
]}

KERR, B ^{[1
]}

MULLEY, J ^{[1
]}

TURNER, G ^{[1
]}

机构：

[1] PRINCE WALES CHILDRENS HOSP,DEPT MED GENET,SYDNEY,NSW,AUSTRALIA

来源：

JOURNAL OF MEDICAL GENETICS | 1991年 / 28卷 / 06期

关键词：

D O I：

10.1136/jmg.28.6.372

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A family is described with five affected males segregating a new gene for non-specific X linked mental retardation (MRX). Linkage analysis localised the gene at Xq28-qter. The maximum lod score was 2.89 with DXS52 (St14) at theta = 0.0. A recombinant was observed with DXS304 (U6.2) defining the proximal limit to the localisation. No evidence for linkage was determined using markers at several points along the remainder of the X chromosome, including the regions known to contain MRX1 and MRX2. This delineates the third gene for non-specific X linked mental retardation, MRX3.

引用

页码：372 / 377

页数：6

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