PLATELET SUPEROXIDE-DISMUTASE IN MIGRAINE AND TENSION-TYPE HEADACHE

被引：59

作者：

SHIMOMURA, T

KOWA, H

NAKANO, T

KITANO, A

MARUKAWA, H

URAKAMI, K

TAKAHASHI, K

机构：

[1] Division of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago

来源：

CEPHALALGIA | 1994年 / 14卷 / 03期

关键词：

MIGRAINE WITH AURA; MIGRAINE WITHOUT AURA; PLATELET; SUPEROXIDE DISMUTASE; TENSION-TYPE HEADACHE;

D O I：

10.1046/j.1468-2982.1994.014003215.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Superoxide dismutase (SOD) is a radical-scavenging enzyme. We determined Cu, Zn-SOD concentrations and activities in platelets from subjects with migraine and tension-type headaches. Thirty migraine without aura (MWoA) patients, 9 migraine with aura (MWA) patients, and 53 tension-type headache patients were selected for study. Thirty healthy volunteers composed the control group. Concentrations of platelet SOD were determined using enzyme-linked immunosorbent assay techniques. The activity of platelet SOD was determined by measuring reductivity of nitroblue tetrazolium. Low concentrations of platelet SOD were found in patients with MWA and MWoA. Platelet SOD activity decreased in MWA patients but not in patients with MWoA or tension-type headaches. These findings suggest vulnerability to oxidative stress in patients with migraine. It is suggested that low platelet SOD levels may play an important role in the etiology of migraine.

引用

页码：215 / 218

页数：4

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