NEW HEPARIN-LIKE INSOLUBLE MATERIALS .2.

Heparin-like insoluble materials were prepared by reacting different α-amino acids with cross-linked chlorosulfonated polystyrene. The amount of thrombin inactivated by these resins, when suspended in plasma, is linearly dependent upon the polymer content for all the materials studied and upon the thrombin concentrations examined. The anticoagulant potency of each resin can be expressed as the activity of the sulfonate groups added to the activity of the α-amino acid sulfamide groups linked to polystyrene. The activity coefficients of substituting groups increase according to the following sequence: (1) -SO2 But NH2; (2) -SO3-, -SO2 Ala, -SO2 Phe; (3) -SO2 Met, -SO2 OH Pro, -SO2 Pro, -SO2 Thr, -SO2 Z Lys; (4) -SO2 Glu. © 1980 Pergamon Press Ltd.