THE INFLUENCE OF ADRENALECTOMY ON ALPHA-ADRENOCEPTOR RESPONSES IN RAT CEREBRAL-CORTEX SLICES

被引：15

作者：

ROBINSON, JP

KENDALL, DA

机构：

[1] Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham

来源：

MOLECULAR BRAIN RESEARCH | 1990年 / 7卷 / 01期

关键词：

Adrenalectomy; Cyclic adenosine monophosphate; Metopirone; Phorbol ester; α[!sub]1[!/sub]-Adrenoceptor; β-Adrenoceptor;

D O I：

10.1016/0169-328X(90)90075-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Experiments were undertaken to examine the effect of depletion of adrenal steroids on neurotransmitter-stimulated cAMP accumulation in rat cerebral cortex slices. Long-term depletion due to bilateral adrenalectomy (ADX) and short term depletion due to the steroid synthesis inhibitor metopirone (MET) caused a significant increase in α1-adrenoceptor-mediated potentiation of β-adrenoceptor-stimulated cAMP accumulation. The effect of MET was prevented by corticosterone treatment. This effect of ADX was selective in that there was no change in α1-adrenoceptor-mediated inositol phosphate accumulation. In addition, ADX had no effect on potentiation of isoprenaline-stimulated cAMP by either the GABAB agonist baclofen or the phorbol ester, 4β-phorbol dibutyrate. However, 2-chloroadenosine-stimulated cAMP accumulation was significantly reduced in ADX rats. © 1990.

引用

页码：69 / 74

页数：6

共 24 条

[1] RECEPTOR-MEDIATED ACTIVATION OF PHOSPHOLIPASE-A2 VIA GTP-BINDING PROTEINS - ARACHIDONIC-ACID AND ITS METABOLITES AS 2ND MESSENGERS [J].