CYCLIC AMP-INDEPENDENT ACTIVATION OF TRANSCRIPTION FACTOR NF-KAPPA-B IN HL-60 CELLS BY TUMOR-NECROSIS-FACTOR-ALPHA AND FACTOR-BETA

被引：25

作者：

HOHMANN, HP ^{[1
]}

KOLBECK, R ^{[1
]}

REMY, R ^{[1
]}

VANLOON, APGM ^{[1
]}

机构：

[1] F HOFFMANN LA ROCHE & CO LTD,CENT RES UNIT,CH-4002 BASEL,SWITZERLAND

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1991年 / 11卷 / 04期

关键词：

D O I：

10.1128/MCB.11.4.2315

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

No correlation exists in HL60 cells between NF-kappa-B activation by tumor necrosis factor (TNF-alpha) and TNF-beta and intracellular levels of cyclic AMP. Cyclic AMP levels did not increase upon treatment of cells with each of these cytokines, although NF-kappa-B was activated. Forskolin or 1-isobutyl-3-methylxanthine drastically increased intracellular levels of cyclic AMP, but neither activated NF-kappa-B nor influenced TNF-induced NF-kappa-B activation.

引用

页码：2315 / 2318

页数：4

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