REGULATION OF ARGININE VASOPRESSIN MESSENGER-RNA IN RAT FETAL HYPOTHALAMIC CELL-CULTURE - ROLE OF PROTEIN-KINASES AND GLUCOCORTICOIDS

被引：12

作者：

HU, SB

TANNAHILL, LA

LIGHTMAN, SL

机构：

[1] Neuroendocrinology Unit, Charing Cross/Westminster Med. Sch., Charing Cross Hospital, London W6 8RF, Fulham Palace Road

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 1993年 / 10卷 / 01期

关键词：

D O I：

10.1677/jme.0.0100051

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Studies have been performed to investigate the regulation of arginine vasopressin (AVP) mRNA expression in fetal hypothalamic cultures. AVP mRNA-positive neurones were identified by in-situ hybridization histochemistry, and changes in mRNA expression were quantitated by nuclease protection assay. Both protein kinase C and protein kinase A activators increased the expression of AVP mRNA, in contrast to dexamethasone, which inhibited the responses to both protein kinase C and protein kinase A activation.

引用

页码：51 / 57

页数：7

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