SEVERE OVARIAN HYPERSTIMULATION SYNDROME IN ASSISTED REPRODUCTIVE TECHNOLOGY - DEFINITION OF HIGH-RISK GROUPS

被引：173

作者：

ASCH, RH

LI, HP

BALMACEDA, JP

WECKSTEIN, LN

STONE, SC

机构：

[1] Department of Obstetrics and Gynaecology, Air Force General Hospital, Taipei

[2] Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of California, Irvine

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 10期

关键词：

ASSISTED REPRODUCTIVE TECHNOLOGY; OVARIAN STIMULATION; FOLLICULAR ASPIRATION; OVARIAN HYPERSTIMULATION SYNDROME;

D O I：

10.1093/oxfordjournals.humrep.a137276

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

In a retrospective analysis of 637 cycles of ovarian stimulation and transvaginal follicular aspiration for various assisted reproductive technologies, severe ovarian hyperstimulation syndrome (SOH) occurred in six (0.94%) cycles. The patients at a high risk of developing SOH in cycles of assisted reproduction were those who had excessive serum oestradiol levels on the day of human chorionic gonadotrophin (HCG) administration (oestradiol > 6000 pg/ml; 38% SOH) and a high number of oocytes obtained (> 30 oocytes; 23% SOH). In those patients with both oestradiol > 6000 pg/ml on the day of HCG administration and > 30 eggs retrieved, the chance of developing SOH was 80%. The higher the serum oestradiol levels and the more eggs retrieved, the higher the pregnancy rates observed. High oestradiol level did not appear to have a detrimental effect on pregnancy rates and outcome. Furthermore, our results are not consistent with suggestions that the addition of gonadotrophin-releasing hormone agonist to ovarian stimulation protocols, follicular aspiration and/or luteal support with progesterone may reduce the incidence of ovarian hyperstimulation syndrome.

引用

页码：1395 / 1399

页数：5

共 24 条

[1]

Asch R.H., Balmaceda J.P., Ellsworth L.R., Wong P.C., Preliminary experiences with gamete intrafallopian transfer (GIFT), Fertil. Steril, 45, pp. 366-371, (1986)

[2]

Balmaceda J.P., Borrero C., Gastaldi C., Ord T., Remohi J., Asch R.H., Tubal embryo transfer as a treatment for infertility due to male factor, Fertil. Steril, 50, pp. 476-479, (1988)

[3]

Blankstein J., Pariente C., Shalev J., Lunenfeld B., Saadon T., Serr D.M., Kukia E.E., Mashiach S., Rabinovici J., Ovarian hyperstimulation syndrome: Prediction by number and size of preovulatory ovarian follicles, Fertil. Steril, 47, pp. 597-602, (1987)

[4]

Chenette P.E., Sauer M.V., Paulson R.J., Very high serum estradiol levels are not detrimental to clinical outcome of in vitro fertilization, Fenil. Steril, 54, pp. 858-863, (1990)

[5]

Forman R., Ross C., Frydman R., Barlow D., Egan D., Fertil. Steril, 53, pp. 502-509, (1990)

[6]

Fnedman C., Schmidt G.E., Chang F.E., Kim M.H., Severe ovarian hyperstimulation following follicular aspiration Am, J. Obstet. Gynecol, 150, pp. 436-437, (1984)

[7]

Gerli S., Remohi J., Patrizio P., Borrero C., Balmaceda J.P., Silber S.J., Asch R.H., Programming of ovarian stimulation with norethindrone acetate in FVF/GIFT cycles, Hum. Reprod, 4, pp. 746-748, (1989)

[8]

Gidley-Baird A.A., O'neill C., Sinosich M.J., Porter R.N., Pike I.L., Saunders D.M., Failure of implantation in human in vitro fertilization and embryo transfer patients: The effects of altered progesterone/estrogen ratios in humans and mice, Fertil. Steril, 45, pp. 69-74, (1986)

[9]

Golan A., Weinraub Z., Ron E.R., Soffer Y., Herman A., Caspi E., Ovarian hyperstimulation syndrome following D-Trp-6 luteinizing hormone-releasing hormone microcapsules and menotropin for in vitro fertilization, Fertil. Steril, 50, pp. 912-916, (1988)

[10]

Hampton H.L., Whitworth N.S., Cowan B.D., Gonadotropinreleasing hormone agonist (Leuprolide acetate) induced ovarian hyperstimulation syndrome in a woman undergoing intermittent hemodialysis, Fertil. Steril, 55, pp. 429-431, (1991)

← 1 2 3 →