SYNTHESIS OF (E)-BETA,GAMMA-UNSATURATED GAMMA-AMINO-ACIDS BY REARRANGEMENT OF ALLYTRICHLORACETIMIDATES

被引：52

作者：

MEHMANDOUST, M

PETIT, Y

LARCHEVEQUE, M

机构：

[1] Ecole Normale Supérieure, Laboratoire de Chimie associé au CNRS, 75231 Paris Cedex 05

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(00)74248-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pure (E)-beta,gamma-unsaturated alpha-aminoacids of high enantiomerical purity were synthesized by Pd(II) catalyzed rearrangement of trichloracetimidates derived from optically pure monoprotected diallylalcohols. After cyclisation of the resulting N-trichloracetyl allylic amines into unsaturated oxazolidinones, these intermediates were transformed into N-Boc-aminoalcohols and oxidized with molecular oxygen in the presence of platinum.

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页码：4313 / 4316

页数：4

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