ANTIBACTERIAL ACTIVITY OF SUCRALFATE AGAINST ESCHERICHIA-COLI, STAPHYLOCOCCUS-AUREUS AND PSEUDOMONAS-AERUGINOSA IN BATCH AND CONTINUOUS-CULTURE

被引：17

作者：

WEST, AP ^{[1
]}

ABDUL, S ^{[1
]}

SHERRATT, MJ ^{[1
]}

INGLIS, TJJ ^{[1
]}

机构：

[1] NATL UNIV SINGAPORE,FAC MED,DEPT MICROBIOL,SINGAPORE 0511,SINGAPORE

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1993年 / 12卷 / 11期

关键词：

D O I：

10.1007/BF02000412

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The antibacterial effect of varying concentrations of sucralfate was studied on Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus grown in both agitated batch and continuous culture. The minimum inhibitory concentrations estimated with the two methods were in close agreement, ranging from 5 to 15 mg sucralfate/ml, concentrations easily attainable in gastric juice after a standard adult dose. Batch culture results indicated a dose-dependent effect. This study provides further evidence for an antibacterial effect by sucralfate against a range of species associated with respiratory tract infection in ventilated patients.

引用

页码：869 / 871

页数：3

共 6 条

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