THE ANATOMY OF A MOLECULAR GIANT - HOW THE SARCOMERE CYTOSKELETON IS ASSEMBLED FROM IMMUNOGLOBULIN SUPERFAMILY MOLECULES

被引：50

作者：

FURST, DO ^{[1
]}

GAUTEL, M ^{[1
]}

机构：

[1] EUROPEAN MOLEC BIOL LAB, HEIDELBERG, GERMANY

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 1995年 / 27卷 / 04期

关键词：

TITIN; C-PROTEIN; M-PROTEIN; H-PROTEIN; MYOMESIN; TWITCHIN; IMMUNOGLOBULIN SUPERFAMILY; FIBRONECTIN REPEAT; IMMUNOGLOBULIN DOMAIN; MYOGENESIS;

D O I：

10.1016/0022-2828(95)90064-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cross-striated muscle contains an elastic cytoskeleton comprised of the giant protein titin and several associated proteins. cDNA sequencing revealed that all these proteins are immunoglobulin superfamily members. This modular Structure opens the possibility to dissect the proteins involved into functional units and to approach the problem of structure-function correlation at the molecular level.

引用

页码：951 / 959

页数：9

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