NEW PENICILLINS FROM ISOPENICILLIN-N SYNTHASE

被引：13

作者：

BALDWIN, JE ^{[1
]}

BRADLEY, M ^{[1
]}

ABBOTT, SD ^{[1
]}

ADLINGTON, RM ^{[1
]}

机构：

[1] OXFORD CTR MOLEC SCI,OXFORD 0X1 3QY,ENGLAND

来源：

TETRAHEDRON | 1991年 / 47卷 / 28期

关键词：

D O I：

10.1016/S0040-4020(01)87142-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The three tripeptides delta-L-alpha-aminoadipoyl-L-cysteinyl-D-propargylglycine, delta-L-alpha-aminoadipoyl-L-cysteinyl-D-cyanoalanine and delta-L-alpha-aminoadipoyl-L-cysteinyl-D-[4,4,5,5-2H4]-norvaline were synthesised and incubated with the enzyme Isopenicillin N Synthase (IPNS). All incubation mixtures contained biologically active products, and led to the isolation of four new penicillins (beta-ethyl, alpha-acetylenic, alpha- and beta-nitrile) following purification by reverse phase HPLC. The stereochemistries of formation of monosubstituted penicillins with IPNS are rationalised.

引用

页码：5309 / 5328

页数：20

共 24 条

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