TJIPANAZOLES, NEW ANTIFUNGAL AGENTS FROM THE BLUE-GREEN-ALGA TOLYPOTHRIX-TJIPANASENSIS

被引：117

作者：

BONJOUKLIAN, R ^{[1
]}

SMITKA, TA ^{[1
]}

DOOLIN, LE ^{[1
]}

MOLLOY, RM ^{[1
]}

DEBONO, M ^{[1
]}

SHAFFER, SA ^{[1
]}

MOORE, RE ^{[1
]}

STEWART, JB ^{[1
]}

PATTERSON, GML ^{[1
]}

机构：

[1] UNIV HAWAII,DEPT CHEM,HONOLULU,HI 96822

来源：

TETRAHEDRON | 1991年 / 47卷 / 37期

关键词：

D O I：

10.1016/S0040-4020(01)81932-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioactivity-directed isolation of the extract of the cyanophyte Tolypothrix tjipanasensis has led to the isolation of fifteen new N-glycosides of indolo[2,3-a]carbazoles designated tjipanazoles A1, A2, B, C1, C2, C3, C4, D, E, F1, F2, G1, G2, I and J. The structures of the alkaloids were determined by physical methods, chemical degradation and synthesis. Tjipanazole J is the only compound having the pyrrolo[3,4-c] ring of previously described indolo[2,3-a]carbazoles.

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页码：7739 / 7750

页数：12

相关论文

共 17 条

[1] PRODUCTION AND BIOLOGICAL-ACTIVITY OF REBECCAMYCIN, A NOVEL ANTITUMOR AGENT [J].

BUSH, JA ;

LONG, BH ;

CATINO, JJ ;

BRADNER, WT .

JOURNAL OF ANTIBIOTICS, 1987, 40 (05) :668-678

[2] REACTIONS AT POSITION 1 OF CARBOHYDRATES .V. NUCLEOPHILIC DISPLACEMENT REACTIONS OF ACETYLGLYCOSYL HALIDES [J].

CAPON, B ;

COLLINS, PM ;

LEVY, AA ;

OVEREND, WG .

JOURNAL OF THE CHEMICAL SOCIETY, 1964, (SEP) :3242-&

[3]

CORBETT TH, 1988, P AM ASSOC CANC RES, V29, P533

[4] CONFORMATIONAL STUDIES ON PYRANOID SUGAR DERIVATIVES BY NMR SPECTROSCOPY - CONFORMATIONAL EQUILIBRIA OF PERACETYLATED AND SOME PERBENZOYLATED METHYL D-ALDO-PENTOPYRANOSIDES IN SOLUTION [J].

DURETTE, PL ;

HORTON, D .

CARBOHYDRATE RESEARCH, 1971, 18 (03) :403-&

[5] Triacetyl-d-xylose and alpha triacetylmethyl-d-xyloside [J].

Hudson, CS ;

Dale, JK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1918, 40 :997-1001

[6]

KNUBEL G, 1990, J ANTIBIOT, V43, P1236

[7] PYRANOSE BENZOATES - AN ADDITIVITY RELATION IN THE AMPLITUDES OF EXCITON-SPLIT CD CURVES [J].

LIU, HW ;

NAKANISHI, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (05) :1178-1185

[8] THE SYNTHESIS OF INDOLO(2',3'-1,2)-CARBOZOLE AND INDOLO(3',2'-1,2)-CARBAZOLE [J].

MANN, FG ;

WILLCOX, TJ .

JOURNAL OF THE CHEMICAL SOCIETY, 1958, (APR) :1525-1529

[9] HAPALINDOLES, ANTIBACTERIAL AND ANTIMYCOTIC ALKALOIDS FROM THE CYANOPHYTE HAPALOSIPHON-FONTINALIS [J].

MOORE, RE ;

CHEUK, C ;

YANG, XQG ;

PATTERSON, GML ;

BONJOUKLIAN, R ;

SMITKA, TA ;

MYNDERSE, JS ;

FOSTER, RS ;

JONES, ND ;

SWARTZENDRUBER, JK ;

DEETER, JB .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (06) :1036-1043

[10]

NAKANISHI S, 1986, J ANTIBIOT, V39, P1066