NEW TELEOCIDIN-RELATED METABOLITES, (-)-7-GERANYLINDOLACTAM-V AND BLASTMYCETIN-F, FROM STREPTOVERTICILLIUM-BLASTMYCETICUM

被引：5

作者：

IRIE, K

KAJIYAMA, SI

OKUNO, S

KONDO, M

KOSHIMIZU, K

HAYASHI, H

ARAI, M

NISHINO, H

IWASHIMA, A

机构：

[1] UNIV OSAKA PREFECTURE,COLL AGR,DEPT AGR CHEM,SAKAI,OSAKA 593,JAPAN

[2] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KAMIKYO KU,KYOTO 602,JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 03期

关键词：

D O I：

10.1021/np50105a005

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new teleocidin-related metabolites, (-)-7-geranylindolactam-V [2] and blastmycetin F [3], were isolated from fermentation broths of the actinomycete Streptoverticillium blastmyceticum NA34-17, and their structures were determined by spectroscopic methods. Compound 2 bound strongly to phorbol ester receptors in a mouse epidermal particulate fraction, suggesting that it is a potent in vivo rumor promoter comparable to teleocidins A-1 [4] and B-4 [5].

引用

页码：363 / 368

页数：6

共 32 条

[1] DIRECT MEASUREMENT OF SPECIFIC BINDING OF HIGHLY LIPOPHILIC PHORBOL DIESTER TO MOUSE EPIDERMAL MEMBRANES USING COLD ACETONE
ASHENDEL, CL
BOUTWELL, RK
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 99 (02) : 543 - 549
[2] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR
BAX, A
SUMMERS, MF
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) : 2093 - 2094
[3] SEAWEED DERMATITIS - STRUCTURE OF LYNGBYATOXIN-A
CARDELLINA, JH
MARNER, FJ
MOORE, RE
[J]. SCIENCE, 1979, 204 (4389) : 193 - 195
[4] SYNTHESIS AND STEREOCHEMISTRY OF INDOLACTAM-V, AN ACTIVE FRAGMENT OF TELEOCIDINS - STRUCTURAL REQUIREMENTS FOR TUMOR-PROMOTING ACTIVITY
ENDO, Y
SHUDO, K
ITAI, A
HASEGAWA, M
SAKAI, S
[J]. TETRAHEDRON, 1986, 42 (21) : 5905 - 5924
[5] FUJIKI H, 1988, CANCER RES, V48, P4211
[6] INDOLE ALKALOIDS - DIHYDROTELEOCIDIN-B, TELEOCIDIN, AND LYNGBYATOXIN-A AS MEMBERS OF A NEW CLASS OF TUMOR PROMOTERS
FUJIKI, H
MORI, M
NAKAYASU, M
TERADA, M
SUGIMURA, T
MOORE, RE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (06): : 3872 - 3876
[7] HAGIWARA N, 1988, AGR BIOL CHEM TOKYO, V52, P641
[8] THE METABOLISM OF INDOLE ALKALOID TUMOR PROMOTER, (-)-INDOLACTAM-V, WHICH HAS THE FUNDAMENTAL STRUCTURE OF TELEOCIDINS, BY RAT-LIVER MICROSOMES
HAGIWARA, N
IRIE, K
TOKUDA, H
KOSHIMIZU, K
[J]. CARCINOGENESIS, 1987, 8 (07) : 963 - 965
[9] X-RAY STRUCTURE DETERMINATION OF DIHYDROTELEOCIDIN B MONOBROMOACETATE
HARADA, H
SAKABE, N
HIRATA, Y
[J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1966, 39 (08) : 1773 - +
[10] COLOUR REACTIONS OF HYDROXYSKATOLES
HEACOCK, RA
MAHON, ME
[J]. JOURNAL OF CHROMATOGRAPHY, 1965, 17 (02): : 338 - &

← 1 2 3 4 →