C-TYPE NATRIURETIC PEPTIDE INHIBITS INTIMAL THICKENING OF RABBIT CAROTID-ARTERY AFTER BALLOON CATHETER INJURY

被引：40

作者：

SHINOMIYA, M

TASHIRO, J

SAITO, Y

YOSHIDA, S

FURUYA, M

OKA, N

TANAKA, S

KANGAWA, K

MATSUO, H

机构：

[1] YAMAGATA UNIV,SCH MED,DEPT LAB MED,YAMAGATA 99023,JAPAN

[2] SUNTORY INST BIOMED RES,MISHIMA,SHIZUOKA 618,JAPAN

[3] NATL CARDIOVASC CTR,RES INST,SUITA,OSAKA 565,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 205卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.2772

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

C-type natriuretic peptide (CNP) stimulated cGMP production in rabbit cultured vascular smooth muscle cells, and thymidine uptake was inhibited by CNP. We tested whether CNP inhibits the development of intimal lesions induced by balloon catheter injury in rabbit common carotid artery. CNP (1 mu g/kg/min) infusion through the left jugular vein by DIB balloon catheter pump was started at 30 min before injury and continued until sacrifice. The median of the mean ratio of intima to media in each rabbit after 14 days was 29.5% [14.5 - 57.8] for control group and 12.0% [2.5 - 29.8] for CNP group (p<0.01). Maximum ratio was also significantly low in CNP group. These results suggest that CNP may act as local regulator which suppresses intimal thickening. (C) 1994 Academic Press, Inc.

引用

收藏

页码：1051 / 1056

页数：6

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