SYNTHESIS OF SEROTONIN BY PINEAL GLANDS OF RAT IN ORGAN CULTURE

被引：45

作者：

SHEIN, HM

WURTMAN, RJ

AXELROD, J

机构：

来源：

NATURE | 1967年 / 213卷 / 5077期

关键词：

D O I：

10.1038/213730a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A technique for cultivating the pineal glands of adult rats, so that serotonin is synthesized from the amino-acids tryptophan and 5-hvdroxytryptophan with a rate that increases during the first 4 days in culture is described. Additional investiga-tions provide evidence for the continuing activity of both the enzymes required for serotonin synthesis (tryptophan hydroxylase and 5-hydroxytryptophan decarboxylase), and for a rate-limiting role of tryptophan hydroxylase in the formation of this amine.

引用

页码：730 / +

页数：1

共 14 条

[1]

AXELROD J, 1961, J BIOL CHEM, V236, P211

[2]

AXELROD J, 1965, J BIOL CHEM, V240, P949

[3]

Chlopina JD, 1941, CR ACAD SCI URSS, V31, P707

[4]

HUNGERFORD G F, 1965, Prog Brain Res, V10, P465

[5]

HUNGERFORD GF, 1962, Z ZELLFORSCH MIK ANA, V57, P809

[6]

KASAHARA S, 1933, T JAP PATH SOC, V23, P455

[7]

NAKAMURA S, 1965, FED PROC, V24, P604

[8]

PARKER RC, 1961, METHODS TISSUE CULTU, pCH10

[9] CIRCADIAN RHYTHM IN RAT PINEAL SEROTONIN AND ITS MODIFICATIONS BY ESTROUS CYCLE AND PHOTOPERIOD [J].

QUAY, WB .

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1963, 3 (05) :473-479

[10] A SENSITIVE AND SPECIFIC FLUORESCENCE ASSAY FOR TISSUE SEROTONIN [J].

SNYDER, SH ;

AXELROD, J ;

ZWEIG, M .

BIOCHEMICAL PHARMACOLOGY, 1965, 14 (05) :831-&

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