ANTIBODY-RESPONSE TO PRES1 IN HEPATITIS-B-VIRUS-INDUCED LIVER-DISEASE AND AFTER IMMUNIZATION

被引：8

作者：

COURSAGET, P

BUISSON, Y

BOURDIL, C

YVONNET, B

MOLINIE, C

DIOP, MT

CHIRON, JP

BAO, O

DIOPMAR, I

机构：

[1] FAC PHARM TOURS,MICROBIOL LAB,F-37042 TOURS,FRANCE

[2] HOP INSTRUCT ARMEES VAL DE GRACE,F-75230 PARIS 05,FRANCE

[3] HOP INSTRUCT ARMEES BEGIN,F-94160 ST MANDE,FRANCE

[4] FAC MED & PHARM DAKAR,DAKAR,SENEGAMBIA

来源：

RESEARCH IN VIROLOGY | 1990年 / 141卷 / 05期

关键词：

Hepatitis B; Immunity; Protein preS1; Vaccine;

D O I：

10.1016/0923-2516(90)90087-Y

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Antibodies to the preS1-encoded sequence of hepatitis B virus (HBV) envelope were detected by ELISA using a synthetic peptide analogue of preS1 proteins, in different groups of HBV-infected subjects and also in hepatitis B vaccine recipients. Such antibodies were specifically found in only 1 % of HBsAg chronic carriers including patients with cirrhosis and primary liver cancer. Anti-preS1 were detected in patients with acute hepatitis; in 13 % of the HBsAg+ sera obtained before recovery and in 37 % of the sera obtained after recovery. Anti-preS1 antibodies were detected in recipients of a plasma-derived vaccine, but not in those receiving a recombinant vaccine. The results indicate that anti-preS1 is an earlier serum marker of HBV clearance than anti-preS2 and anti-S antibodies. © 1990.

引用

页码：563 / 570

页数：8

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