REGULATION OF ISOTYPE IMMUNOGLOBULIN PRODUCTION BY ADJUVANTS INVIVO

被引：53

作者：

KARAGOUNI, EE ^{[1
]}

HADJIPETROUKOUROUNAKIS, L ^{[1
]}

机构：

[1] ARISTOTELIAN UNIV SALONIKA,SCH SCI,FAC BIOL,DEPT GENET DEV & MOLEC BIOL,SALONIKA,GREECE

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1990年 / 31卷 / 06期

关键词：

D O I：

10.1111/j.1365-3083.1990.tb02826.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice were immunized against fiuorescein isothiocyanate (FITC)‐labelled human gamma globulin (HGG) or dexlran sulphate (DXS) in the absenee or presence of different adjuvants. The immune response was assayed as the total Ig‐secreting cells and FITC‐speeilic plaque‐forming cells (PFC) found in various lymphoid organs. The adjuvants inliueneed the isolype of antibodies produced to the same antigenic determinant. The PFC of different IgG subclasses were favoured by different adjuvants. The IgG3 isotype was produecd mainly alter immunization with either anligen and lipopolysaccharide(LPS)or Li sail asadjusani; IgGI was produced with incomplete Feund's adjuvant (IFA), complete Freund's adjuvani (CFA), alum, poly I:C. Quil A, Be salt, and poly A:U. Some of the above adjuvanis (Be salt and poly A:U) favoured the production of lgG2b, and others (CFA, alum. Quil A, and poly I:C) favoured ihe IgG2a isotype besides the main isotype. Attempts were made to correlate the activation by the various adjuvants of certain TH subtypes with the isotypes produced. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：745 / 754

页数：10

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