CARDIOTONIC-C RING MODIFIED ISOMAZOLE ANALOGS

被引：5

作者：

BARRACLOUGH, P

BLACK, JW

CAMBRIDGE, D

DEMAINE, DA

GERSKOWITCH, VP

GILES, H

HILL, AP

HULL, RAD

LYER, R

KING, WR

LIVINGSTONE, DJ

NOBBS, MS

RANDALL, P

SHAH, GP

WHITING, MV

机构：

[1] WELLCOME RES LABS,DEPT PHARMACOL,BECKENHAM BR3 3BS,KENT,ENGLAND

[2] WELLCOME RES LABS,DEPT PHYS SCI,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

ARCHIV DER PHARMAZIE | 1990年 / 323卷 / 08期

关键词：

D O I：

10.1002/ardp.19903230812

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Isomazole analogues which have achiral electron withdrawing substituents at the 4′‐position and analogues with heterocyclic ‘C’ rings have been synthesized and evaluated as inotropic agents. It was found that pyridyl could replace phenyl in the ‘C’ ring without loss of activity. The 4′‐methylsulphonyl, ‐cyano, ‐carboxamido, and acetyl analogues had similar inotropic potencies to Isomazole whilst displaying superior cardiovascular profiles in in vivo studies. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：507 / 512

页数：6

共 17 条

[1] A COMPARATIVE-STUDY OF THE CARDIOVASCULAR AND BIOCHEMICAL ACTIONS OF THE IMIDAZO [4,5B] PYRIDINE SULMAZOLE AND AN IMIDAZO [4,5C] PYRIDINE ANALOG, BW-A746C
ALLAN, G
CAMBRIDGE, D
FOLLENFANT, MJ
STONE, D
WHITING, MV
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1988, 93 (02) : 387 - 398
[2] 2-PYRIDYLIMIDAZOLES AS INHIBITORS OF XANTHINE-OXIDASE
BALDWIN, JJ
LUMMA, PK
NOVELLO, FC
PONTICELLO, GS
SPRAGUE, JM
DUGGAN, DE
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (09) : 1189 - 1193
[3] AN ADVENTITIOUS SYNTHESIS OF A 5-METHYLIMIDAZO[4,5-C]PYRIDINE DERIVATIVE
BARRACLOUGH, P
IYER, R
LINDON, JC
WILLIAMS, JM
[J]. TETRAHEDRON LETTERS, 1986, 27 (49) : 5997 - 6000
[4] SIMPLE PYRIMIDINES .X. FORMATION AND REACTIVITY OF 2-, 4-, AND 5-PYRIMIDINYL SULPHONES AND SULPHOXIDES
BROWN, DJ
FORD, PW
[J]. JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1967, (07): : 568 - &
[5] PREPARATION OF 2-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES CONTAINING FERROIN GROUP
CASE, FH
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1967, 4 (01) : 157 - &
[6] Foks H, 1968, Acta Pol Pharm, V25, P137
[7] SYNTHESES OF (+)-AND (-)-2-METHOXY-4-(S-METHYL-N-[(4-METHYLPHENYL)-SULFONYL]-SULFONIMIDOYL)-BENZOIC ACIDS AND THEIR ABSOLUTE-CONFIGURATIONS
JONAS, R
WURZIGER, H
[J]. TETRAHEDRON, 1987, 43 (20) : 4539 - 4547
[8] ISOMAZOLE, SYNTHESIS OF THE ENANTIOMERS
JONAS, R
WURZIGER, H
[J]. ARCHIV DER PHARMAZIE, 1986, 319 (12) : 1150 - 1152
[9] KITAGAWA T, 1981, CHEM PHARM BULL, V29, P1130
[10] KUTTER E, 1981, ARZNEIMITTEL-FORSCH, V31-1, P135

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