ULFS-49 CAUSES BRADYCARDIA WITHOUT DECREASING RIGHT VENTRICULAR SYSTOLIC AND DIASTOLIC PERFORMANCE

The effects of ULFS-49, a new calcium channel blocker, on right ventricular (RV) systolic and diastolic performance were evaluated in nine anesthetized, closed-chest dogs by load-insensitive indexes. ULFS-49 (0.3 mg/kg) decreased heart rate (HR) from 76 +/- 25 to 47 +/- 11 beats/min (p < 0.01) and cardiac output (CO) from 1.89 +/- 0.62 to 1.42 +/- 0.72 L/min (p < 0.01), as RV free wall end-diastolic area increased from 486 +/- 126 to 581 +/- 45 mm2 (p < 0.01) and RV end-diastolic volume increased from 66.6 +/- 26.4 to 85.3 +/- 28.5 ml (p < 0.05). Pacing at 100 beats/min ablated these hemodynamic and dimensional changes. RV free wall contractility was assessed by the slope and midrange intercept values of the relation between RV end-systolic pressure (P(es)) and end-systolic free wall area (A(es)) and between RV free wall segmental work (SW) and end-diastolic area (A(ed)). RV free wall stiffness was measured by exponential fit of the RV end-diastolic pressure (P(ed))-A(ed) points during caval occlusion. With pacing at 100 beats/min, the slope of the P(es)-A(es) relationship was unchanged by ULFS-49 (0.52 +/- 0.29 vs. 0.60 +/- 0.35 mm Hg/mm2), as was the midrange intercept (382.3 +/- 114.7 vs. 387.1 +/- 121.5 mm2). After administration of ULFS-49, the slope of the SW-A(ed) relation increased from 31.8 +/- 14.4 to 37.3 +/- 17.7 mm Hg . mm2 (p < 0.05) without changing the midrange intercept (410.5 +/- 108.1 mm2 vs. 413.0 +/- 107.0 mm2). Similarly, neither the position nor curvature of the P(ed)-A(ed) relation was changed by ULFS-49. These data demonstrate that ULFS-49 causes significant bradycardia and increases the size of the right ventricle without directly depressing RV free wall systolic or diastolic performance.