EFFICACY OF CLINDAMYCIN PRIMAQUINE VERSUS TRIMETHOPRIM SULFAMETHOXAZOLE IN PRIMARY-TREATMENT OF PNEUMOCYSTIS-CARINII PNEUMONIA

被引:23
作者
RUF, B
ROHDE, I
POHLE, HD
机构
[1] Department of Internal Medicine, Department of Infectious Diseases, Rudolf Virchow University Hospital (Wedding), Freie Universität Berlin, Berlin 65, D-1000
关键词
D O I
10.1007/BF01964466
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Mild to moderately severe Pneumocystis carinii pneumonia in patients with AIDS was treated in a clinical trial with a combination regimen of primaquine and clindamycin, and the efficacy of this regimen was compared with that of the conventional treatment regimen of trimethoprim/sulfamethoxazole. The results revealed that primaquine/clindamycin appears to be an equally effective alternative to trimethoprim/sulfamethoxazole. The spectrum of side-effects was similar for the two regimens; side-effects occurred with equal frequency but appeared to be less severe in patients given primaquine/clindamycin. Because therapy with primaquine and clindamycin was limited to patients with mild to moderate Pneumocystis carinii pneumonia, studies with this regimen in more severe cases are warranted.
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收藏
页码:207 / 210
页数:4
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