TRANSSPLICING OF PRE-MESSENGER-RNA IS PREDICTED TO OCCUR IN A WIDE-RANGE OF ORGANISMS INCLUDING VERTEBRATES

被引：17

作者：

DANDEKAR, T

SIBBALD, PR

机构：

[1] European Molecular Biology Laboratory, D-6900 Heidelberg, Postfach 10 22 09

来源：

NUCLEIC ACIDS RESEARCH | 1990年 / 18卷 / 16期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1093/nar/18.16.4719

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several known trans-splicing RNA structures were used to define a canonical trans-splicing structure which was then used to perform a computer search of the EMBL nucleotide database. In addition to most known trans-splicing structures, many putative new trans-splicing sites were detected. These were found in a broad range of organisms including the vertebrates. Control experiments indicate that the search predicts known false positives at a rate of only 20%. Trans-splicing may therefore be a very wide-spread phenomenon. © 1990 Oxford University Press.

引用

页码：4719 / 4725

页数：7

共 29 条

[1] THE TUBULIN GENE-CLUSTER OF TRYPANOSOMA-BRUCEI STARTS WITH AN INTACT BETA-GENE AND ENDS WITH A TRUNCATED BETA-GENE INTERRUPTED BY A RETROTRANSPOSON-LIKE SEQUENCE [J].