EFFECT OF CALCIUM AND VERAPAMIL ON RENAL-FUNCTION OF RATS DURING TREATMENT WITH STEVIOSIDE

被引：46

作者：

MELIS, MS

SAINATI, AR

机构：

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1991年 / 33卷 / 03期

关键词：

STEVIOSIDE; GLOMERULAR FILTRATION RATE; DIURESIS; FRACTIONAL SODIUM AND POTASSIUM EXCRETION;

D O I：

10.1016/0378-8741(91)90086-S

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A study conducted on rats using classical clearance techniques and arterial pressure measurements showed that stevioside from Stevia rebaudiana leaves produced a fall in systemic blood pressure, as well as diuresis and natriuresis per milliliter of glomerular filtration rate. Verapamil tended to increase the renal and systemic effects of stevioside. In contrast, an infusion of CaCl2 in rats prepared with stevioside induced a marked attenuation of the vasodilating responses of stevioside. These data are consistent with the possibility that stevioside may act as a calcium antagonist, as is the case for verapamil.

引用

页码：257 / 262

页数：6

共 26 条

[1]

ALVAREZ M, 1981, ARCH BIOL TECNOL CUR, V24, P179

[2]

BOECH EMA, 1977, CIENCIA CULTURA, V32, P208

[3]

Boeckh E, 1981, CIENCIA CULTURA, V32, P208

[4]

CURI R, 1986, BRAZ J MED BIOL RES, V19, P771

[5] EFFECTS OF COMBINED RENAL VASODILATATION AND PRESSOR AGENTS ON RENAL HEMODYNAMICS AND TUBULAR REABSORPTION OF SODIUM [J].

EARLEY, LE ;

FRIEDLER, RM .

JOURNAL OF CLINICAL INVESTIGATION, 1966, 45 (04) :542-&

[6]

ENGBRETSON BG, 1987, AM J PHYSIOL, V253, P896

[7]

Farnsworth N. R., 1973, Cosmetics and Perfumery, V88, P27

[8]

FIGUEIREDO JF, 1982, BRAZ J MED BIOL RES, V15, P259

[9]

FURH J, 1955, KLIN WOCHENSCHR, V33, P729

[10] API ZYM - SIMPLE RAPID SYSTEM FOR DETECTION OF BACTERIAL ENZYMES [J].

HUMBLE, MW ;

KING, A ;

PHILLIPS, I .

JOURNAL OF CLINICAL PATHOLOGY, 1977, 30 (03) :275-277

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