A MICROCAPSULE SELF-REGULATING DELIVERY SYSTEM FOR INSULIN

被引：106

作者：

MAKINO, K ^{[1
]}

MACK, EJ ^{[1
]}

OKANO, T ^{[1
]}

KIM, SW ^{[1
]}

机构：

[1] UNIV UTAH,CTR CONTROLLED CHEM DELIVERY,421 WAKARA WAY,SUITE 318,SALT LAKE CITY,UT 84108

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 12卷 / 03期

基金：

美国国家卫生研究院;

关键词：

exchange diffusion; glycosylated insulin; insulin delivery system; microcapsule drug delivery system; self regulating drug delivery;

D O I：

10.1016/0168-3659(90)90104-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The self-regulating insulin delivery systems previously developed in our laboratory utilized the affinity binding of succinyl-amidophenyl-glucopyranoside insulin (SAPG-insulin) to soluble, beadimmobilized or crosslinked concanavalin A (Con A). The systems were enclosed in polymer membranes for in vitro assessment. These devices exhibited long lag times for the dynamic exchange of SAPG-insulin and glucose. A new system was prepared with hydrophilic nylon microcapsules containing Con A and SAPG-insulin. Unbound SAPG-insulin permeation was the rate limiting step for diffusion from the microcapsules. Preliminary in vitro data demonstrated rapid diffusion of both glucose and SAPG-insulin across the microcapsule membrane with a short lag time for exchange. SAPG-insulin was released from a reservoir system (the microcapsules in a pouch membrane) with a quick response to changes in glucose concentration. © 1990.

引用

页码：235 / 239

页数：5

共 11 条

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