INFLUENCE OF NO-DONOR (SIN-1) ON FUNCTIONS OF INFLAMMATORY CELLS

被引：7

作者：

DEMBINSKAKIEC, A

ZMUDA, A

MARCINKIEWICZ, J

SINZINGER, H

GRYGLEWSKI, RJ

机构：

[1] ATHEROSCLEROSIS RES GRP VIENNA,VIENNA,AUSTRIA

[2] NICHOLAS COPERNICUS MED ACAD,INST MICROBIOL,DEPT IMMUNOL,PL-31501 KRAKOW,POLAND

来源：

AGENTS AND ACTIONS | 1991年 / 32卷 / 1-2期

关键词：

D O I：

10.1007/BF01983305

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

NO-donor SIN-1 (0.01-1.0mM) dose-dependently inhibited the basal and FMLP (30.0mM)-stimulated release of beta-glucuronidase from rat peritoneal leukocytes and antigen-specific stimulation of Interleukin-2 production by T-hybridomas. I-123 LDL binding to human lymphocytes was inhibited by Iloprost (1 mM) but activated by SIN-1 (0.3mM). We conclude that beside the smooth muscle cells and platelets the blood inflammatory/immune cells are under the PGI2/NO control, however, the precise regulation as well as physiological importance need further investigation.

引用

页码：37 / 40

页数：4

共 20 条

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