OVEREXPRESSIONS OF C-FOS/JUN MESSENGER-RNA AND THEIR ONCOPROTEINS (FOS/JUN) IN THE MOUSE UTERUS TREATED WITH 3 NATURAL ESTROGENS

被引：34

作者：

MORISHITA, S ^{[1
]}

NIWA, K ^{[1
]}

ICHIGO, S ^{[1
]}

HORI, M ^{[1
]}

MURASE, T ^{[1
]}

FUJIMOTO, J ^{[1
]}

TAMAYA, T ^{[1
]}

机构：

[1] GIFU UNIV,SCH MED,DEPT OBSTET & GYNECOL,GIFU 500,JAPAN

来源：

CANCER LETTERS | 1995年 / 97卷 / 02期

关键词：

C-FOS; C-JUN; ESTROGENS; REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION; ENDOMETRIUM; MOUSE;

D O I：

10.1016/0304-3835(95)03979-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To further understand hormonal carcinogenesis of natural estrogens (estrone, 17 beta-estradiol (E(2)) and estriol), we determined the expressions of c-fos/jun mRNA, and their oncoproteins (Fos/Jun) with intracellular localization in the uterus of ovarectomized mice treated with these estrogens. Mid-term chronic, as well as short-term assays were examined. Of three estrogens examined, mid-term chronic E(2)-treatment significantly increased the expression of c-fos/jun mRNA, and their oncoproteins (Fos/Jun). These were most prominently expressed in glandular cells of E(2)-treated mouse endometrium. Therefore, mid-term chronic E(2)-treatment might partially induce glandular cell transformation of uterine endometrium via overexpression of Fos/Jun.

引用

页码：225 / 231

页数：7

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