VARIATIONS IN LACTOSE NF FROM 2 DIFFERENT SOURCES AND THEIR INFLUENCE ON TABLET PROPERTIES

被引：5

作者：

WHITEMAN, M

YARWOOD, RJ

机构：

[1] Smith Kline and French Laboratories Ltd., Welwyn Garden City, Hertfordshire, England, Mundells

[2] R P Scherer Ltd, Blagrove, Swindon, Wiltshire, England, Frankland Road

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 11期

关键词：

D O I：

10.3109/03639049009025789

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Samples of Lactose NF obtained from one supplier in the UK and one in the USA were examined in terms of their compaction properties. The materials were studied in a model formulation and also in a development formulation. Differences in properties between the samples were shown to depend principally on the particle size, size distribution and specific surface area. The source of lactose can have significant deleterious effects on a multicomponent formulation even when lactose is not the major component. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：1815 / 1827

页数：13

共 9 条

[1]

ALDERBORN G, 1982, ACTA PHARM SUEC, V19, P381

[2] BATCH VARIATION OF MAGNESIUM STEARATE AND ITS EFFECT ON THE DISSOLUTION RATE OF SALICYLIC-ACID FROM SOLID DOSAGE FORMS [J].