ASSESSMENT OF THE GENOTOXIC POTENTIAL OF CARAMEL COLOR-I IN 4 SHORT-TERM TESTS

被引：10

作者：

ADAMS, K

ALLEN, JA

BROOKER, PC

JONES, E

PROUDLOCK, RJ

机构：

[1] Department of Mutagenesis and Cell Biology, Huntingdon Research Centre, Huntingdon

来源：

FOOD AND CHEMICAL TOXICOLOGY | 1992年 / 30卷 / 05期

关键词：

D O I：

10.1016/0278-6915(92)90066-T

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

A battery of three short-term tests in vitro and one in vivo was used to determine the genotoxicity of Caramel Colour I. The results of the bacterial mutation assay, using five strains of Salmonella typhimurium, and the mouse micronucleus assay in vivo showed no evidence of genotoxic activity. Results from both the cytogenetics assay in vitro, using CHO cells, and the mouse lymphoma assay indicated that there was some genotoxic activity associated with Caramel Colour I but only in the absence of S-9 and at very high dose levels.

引用

页码：397 / 402

页数：6

共 23 条

[1]

Abe S., 1980, KROMOSOMO 2, V20, P574

[2]

Aeschbacher H U, 1986, Prog Clin Biol Res, V206, P133

[3]

AESCHBACHER HU, 1981, PROGR FOOD NUTRITION, P279

[4] ABSENCE OF MUTAGENIC ACTIVITY IN SALMONELLA AND OF CLASTOGENIC ACTIVITY IN CHO CELLS OF CARAMEL COLOR-I, COLOR-II, COLOR-III AND COLOR-IV [J].